报告题目：Use gene editing in pluripotent stem cells to treat human diseases
浙江大学血液学研究所所长和医学院党委书记黄河教授，于2018年4月11日邀请了美国希望之城 Jiing-Kuan Yee 教授，进行学术报告。届时，将在浙江大学紫金港校区医学院综合楼705室上午10点举行学术报告，题目为“Use gene editing in pluripotent stem cells to treat human diseases”。届时欢迎各位踊跃参加。本次活动由浙江大学血液学研究所，浙江大学干细胞与转化医学联盟和干细胞与细胞免疫治疗浙江省工程实验室共同举办。
Jiing-Kuan Yee 介绍
Jiing-Kuan Yee got his PHD in University of Texas at Dallas in 1983. From 1983 to 1987, he acted as post-doctoral fellow at University of California, San Diego. Now, he focus their research on the differentiation of hPSCs into β cells for cell replacement therapy to treat type 1 diabetes at City of Hope. The goal of their research program is to evaluate the feasibility and strategy of using human pluripotent stem cells (hPSCs) to treat human diseases. They have extensive research experience in molecular biology, virology and stem cell biology and have published multiple peer reviewed articles in these fields.
Contributions to Science
1. Identification of a liver-specific enhancer (enhancer 2) in the genome of hepatitis B virus (HBV).
2.Generation of VSV-G pseudotyped retroviral vectors.
3. Manipulation of human pluripotent stem cells (PSCs) for disease modeling and cell-based therapy.
References:
Yee, J.-K. A liver-specific enhancer in the core promoter region of human hepatitis B virus. Science 246, 658-661 (1989).
Wang, X., Wang, Y., Wu, X., Wang, J., Wang, Y., Qiu, Z., Chang, T., Huang, H., Lin, R.J. & Yee, J.K. An unbiased approach to study the off-target effect of CRISPR/Cas9 reveals its tolerance of bulge formation in the genomic target Nat. Biotech. 33:175-178 (2015).
Wang, Y., Wang Y., Chang, T., Huang, H. & Yee, J.-K.”Integration-defective lentiviral vector mediates efficient gene editing through homology-directed repair in human embryonic stem cells.” Nucleic Acids Res. 45(5): e29 (2017).
