代表性论文

代表性论文
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Year: 2018

1. Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, Mao J, Chen Y, Lu C, Xie J, Fang Q, Wang Y, Yue R, Li T, Huang H, Orkin SH, Yuan GC, Chen M, Guo G*. Mapping the Mouse Cell Atlas by Microwell-seq. Cell. Accepted.

2. Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki A, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X#, Mulloy JC, Jin J, He C, Chen J. (2018) R-2HG exhibits anti-tumor activity by targeting FTO/MYC signaling. Cell. 11; 90-105. PMID: 29249359.

3. Zhang, J.#, Zhao, J., Dahan, P., Lu, V., Zhang, C., Hu, L., and Teitell M.A.* Metabolism in Pluripotent Stem Cells and Early Mammalian Development. Accepted Cell Metabolism, Corresponding author.

Year: 2017

1. Wang Y, Wang Y, Chang T, Huang H*, Yee JK*. Integration-defective lentiviral vector mediates efficient gene editing through homology-directed repair in human embryonic stem cells. Nucleic Acids Res. 2017 Mar 17;45(5):e29.

2. Wei G, Wang J, Huang H, Zhao Y*. Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia. J Hematol Oncol. 2017 Aug 18;10(1):150.

3. Santoro N, Ruggeri A, Labopin M, Bacigalupo A, Ciceri F, Gülbaş Z, Huang H#, Afanasyev B, Arcese W, Wu D, Koc Y, Tischer J, Santarone S, Giebel S, Mohty M, Nagler A. Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. J Hematol Oncol. 2017;10(1):113.

4. Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, Qian Y, Huang H#, Wang X. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017 Apr;18(4):586-602.

5. Tan Y, Xiao H, Wu D, Luo Y, Lan J, Liu Q, Yu K, Shi J, He J, Zheng W, Lai X, Zhu Y, Du K, Ye Y, Zhao Y, Zheng G, Hu Y, Han X, Zheng Y, Wei G, Cai Z, Huang H*. Combining therapeutic antibodies using basiliximab and etanercept for severe steroid-refractory acute graft-versus-host disease: A multi-center prospective study.Oncoimmunology. 2017 Jan 6;6(3):e1277307.

6. Tie R, Zhang T, Yang B, Fu H, Han B, Yu J, Tan Y, Huang H*. Clinical implications of HLA locus mismatching in unrelated donor hematopoietic cell transplantation: a meta-analysis.Oncotarget. 2017 Apr 8;8(16):27645-27660.

7. Piemontese S, Ciceri F, Labopin M, Arcese W, Kyrcz-Krzemien S, Santarone S, Huang H#, Beelen D, Gorin NC, Craddock C, Gulbas Z, Bacigalupo A, Mohty M, Nagler A. A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia.J Hematol Oncol. 2017 Jan 19;10(1):24.

8. Hu Y, Wu Z, Luo Y, Shi J, Yu J, Pu C, Liang Z, Wei G, Cui Q, Sun J, Jiang J, Xie J, Tan Y, Ni W, Tu J, Wang J, Jin A, Zhang H, Cai Z, Xiao L, Huang H*. Potent Anti-leukemia Activities of Chimeric Antigen Receptor-Modified T Cells against CD19 in Chinese Patients with Relapsed/Refractory Acute Lymphocytic Leukemia. Clin Cancer Res. 2017 Jul 1;23(13):3297-3306.

9. Lin X, Yang L, Wang G, Zi F, Yan H, Guo X, Cai Z*. Interleukin-32alpha promotes the proliferation of multiple myeloma cells by inducing production of IL-6 in bone marrow stromal cells. Oncotarget. 2017 Nov 3;8(54):92841-54.

10. Chen J, He D, Chen Q, Guo X, Yang L, Lin X, Cai Z*. BAFF is involved in macrophage-induced bortezomib resistance in myeloma. Cell death & disease. 2017 Nov 2;8(11):e3161.

11. Gu Y, Zhang J, Ma X, Kim BW, Wang H, Li J, Pan Y, Xu Y, Ding L, Yang L, Guo C, Wu X, Wu J, Wu K, Gan X, Li G, Li L, Forman SJ, Chan WC, Xu R*, Huang W*.Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.Cancer Cell. 2017;32(1):115-128.

12. Jiang X, Wu Z, Lu X, Zhang X, Yu Q, Gan Y, Wu B, Xu Y, Zheng W, Zhang L, Xu F, Ma A, Gan X, Huang S, Yu X, Huang W*, Xu R*. Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a. Oncotarget. 2017;8(43):75050-75064.

13. Ma X, Meng Z, Jin L, Xiao Z, Wang X, Tsark WM, Ding L, Gu Y, Zhang J, Kim B, He M, Gan X, Shively JE, Yu H, Xu R*, Huang W*. CAMK2γ in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation. Oncogene. 2017;36(28):4060-4071.

14. Meng Z, Ma X, Du J, Wang X, He M, Gu Y, Zhang J, Han W, Fang Z, Gan X, Van Ness C, Fu X, Schones DE, Xu R*, Huang W*. CAMK2γ antagonizes mTORC1 activation during hepatocarcinogenesis. Oncogene. 2017;36(17):2446-2456.

15. Yang C, Huang X, Liu H, Xiao F, Wei J, You L, Qian W*. PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242. Oncotarget. 2017 Jun 13;8(24):39185-39197.

16. You L, Liu H, Huang J, Xie W, Wei J, Ye X, Qian W*.The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins. Oncotarget. 2017 Jan 31;8(5):7777-7790.

17. You L, Jin S, Zhu L, Qian W*.Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies. Oncotarget. 2017 Feb 14;8(7):12374-12388.

18. Sun, J. *, Lei, L. *, Tsai, C.M., Wang, Y., Shi, Y., Ouyang, M., Lu, S., Seong, J., Kim, T.J., Wang, P., Huang, M., Xu, X., Nizet, V., Chien, S., Wang. Y. (2017) Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions. Nat Commun, Sep 7 ; 8 (1) : 477. (* Co-first authors).

19. Chandrasekaran, S*, Zhang, J.*, Zhen Sun, Li Zhang, Ross, C.A., Huang, Y., Asara, J. M., Hu, L., Daley G.Q.,Collins, J.J. Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling. Cell Report, 2017 Dec. 5; 21, 10, p2965-2977

20. Zhang, J.*, Zhao, J., Dahan, P., Lu, V., Zhang, C., Hu, L., and Teitell M.A.* Metabolism in Pluripotent Stem Cells and Early Mammalian Development. Accepted Cell Metabolism, Corresponding author

21. Zhang, J.*, Nioi, P., Hu, L., Tounsen, A., Wu, C. J. Human Stem Cell Models Facilitate Translating Human Genetics to Drug Development. Cell Stem Cell, 2017 Aug. 3; 21,2, p161-165 Corresponding author

22. Liu Y, Hu M, Luo D, Yue M, Wang S, Chen X, Zhou Y, Wang Y, Cai Y, Hu X, Ke Y, Yang Z, Hu H*. Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase. Arterioscler Thromb Vasc Biol. 2017 2017，37(11):2075-2086. (corresponding author)

23. Ye F, Huang W, Guo G*. Studying hematopoiesis using single-cell technologies. J Hematol Oncol. 2017 Jan 21;10(1):27.

24. Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, Zhu W, Zhou B, Zhou T, Ouyang H, Wang J, Yuan GC, Duan S, Orkin SH, Guo G*. A Molecular Roadmap for Induced Multi-lineage Trans-differentiation of Fibroblasts by Chemical Combinations. Cell Res. 2017 Jan 27.

25. Weng H, Huang H, Qin X, Zhao BS, Dong L, Wu H, Skibbe J, Hu C, Wang Y, Dore L, Su R, Ferchen K, Li C, Sun M, Lu Z, Jiang X#, Wei M, He C, Chen J. RNA methyltransferase METTL14 blocks myeloid differentiation and promotes leukemogenesis. Cell Stem Cell. [Epub ahead of print] PMID: 29290617.

26. Huang H, Weng H, Sun W, Qin X, Shi H, Zhao BS, Mesquita A, Yuan CL, Hu YC, Hüttelmaier S, Strong J, Su R, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X#, Qu L, Guan JL, He C, Yang J, Chen J. Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability. Nat Cell Biol.In press.

27. Jiang Xi#, Hu C, Ferchen K, Nie J, Cui X, Chen CH, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J, Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy JC, Zheng Y, Diao J, Jin J, Li C, Liu PP, He C, Chen Y, Chen J. (2017) Targeted inhibition of TET1 transcription as a potent therapeutic strategy for acute myeloid leukemia. Nat Commun. 13; 2099. PMID: 29235481.

28. Wang Y, Skibbe JR, Hu C, Dong L, Ferchen K, Su R, Li C, Huang H, Weng H, Huang H, Qin X, Jin J, Chen J, Jiang Xi#. (2017) ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia. Sci Rep.12; 1853. PMID: 28500307.

29. Li Z, Weng H, Su R, Weng X, Zuo Z, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X#, Zhang P, Jin J, He C, Chen J. (2017) FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase. Cancer Cell.31; 127-141. PMID: 28017614.

Year: 2016

1. Lin W, Ma C, Su F, Jiang Y, Lai R, Zhang T, Sun K, Fan L, Cai Z, Li Z, Huang H, Li J, Wang X*. Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.Gut. 2016 Jan 22.

2. Xu Y, Shan W, Li X, Wang B, Liu S, Wang Y, Long Y, Tie R, Wang L, Cai S, Zhang H, Lin Y, Zhang M, Zheng W, Luo Y, Yu X, Yee JK, Ji J, Huang H*. A synthetic three-dimensional niche system facilitates generation of functional hematopoietic cells from human induced pluripotent stem cells (2016). J HematolOncol9(1): 102.

3. Lin W, Ma C, Su F, Jiang Y, Lai R, Zhang T, Sun K, Fan L, Cai Z, Li Z, Huang H, Li J, Wang X*. Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.Gut. 2016 Jan 22.

4. Xiao H, Wang LM, Luo Y, Lai X, Li C, Shi J, Tan Y, Fu S, Wang Y, Zhu N, He J, Zheng W, Yu X, Cai Z, Huang H*. Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic cell transplantation. Oncotarget. 2016. 7(3):2696-708.

5. Gu Y, Zheng W, Zhang J, Gan X, Ma X, Meng Z, Chen T, Lu X, Wu Z, Huang W*, Xu R*. Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis. Leukemia. 2016;30:1282-9.

6. Zhou H, Zhang J, Gu Y, Gan X, Gan Y, Zheng W, Kim BW, Xu X, Lu X, Dong Q, Zheng S, Huang W*, Xu R*. Identification of a novel RNA giant nuclear body in cancer cells. Oncotarget. 2016;7(4):4724-34.

7. Klionsky DJ, Abdelmohsen K, Abe A, Qian WB*, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.

8. Cao W, Guo J, Wen X, Miao L, Lin F, Xu G, Ma R, Yin S, Hui Z, Chen T, Guo S, Chen W, Huang Y, Liu Y, Wang J, Wei L*, Wang L*. CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation. Nat Commun. 2016 May 23;7:11687.

9. Zhang, J.*, Ratanasirintrawoot, S.*, Chandrasekaran, S, Wu, Z., Ficarro, S.B., Yu, C., Cacchiarelli, D., Ross, C.A., Xia, Q., Seligson,M, Shinoda, G., Xie, W., Cahan, P., Wang, L., Shyh-Chang, N., Tintara, S., Trapnell, C., Onder, T., Loh, Y., Asara, J.M., Mikkelsen, T., Teitell, M., Sliz P., Marto, J.M., Hu, L., Collins, J.J., Daley, G. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell, 2016 July 7; 19, 1-15,

10. WangD, Liu Y, Zhang R, Zhang F,Sui W,ChenL, Zheng R, Chen X, Wen F*,OuyangHW*,JiJ*. Apoptotic transition of senescent cells accompanied with mitochondrial hyper-function (2016).Oncotarget7(19): 28286-300 (* Correspondence author).

11. Qian P#, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.Cell Stem Cell. 2016 Feb 4;18(2):214-28. (Cover letter).

12. Kim TH, Saadatpour A, Guo G#, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 Aug 23;16(8):2053-60. doi: 10.1016/j.celrep.2016.07.056.

13. Guo G#，Pinello L, Han X, Lai S, Shen L, Lin TW, Zou K, Yuan GC#, Orkin SH#. Serum-based culture conditions provoke gene expression variability in mouse embryonic stem cells as revealed by single cell analysis. Cell Rep. 2016 Jan 19. doi: 10.1016/j.celrep.2015.12.089.. #Co-corresponding authors.

14. Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G#, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 Sep 29;17(1):201.

15. Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G#, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173.

16. Jiang X#, Hu C, Arnovitz S, Bugno J, Yu M, Zuo Z, Chen P, Huang H, Ulrich B, Gurbuxani S, Weng H, Strong J, Wang Y, Li Y, Salat J, Li S, Elkahloun AG, Yang Y, Neilly MB, Larson RA, Le Beau MM, Herold T, Bohlander SK, Liu PP, Zhang J, Li Z, He C, Jin J, Hong S, Chen J. (2016) miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia. Nat Commun.26; 11452. PMID: 27116251.

17. Jiang X^#, Bugno J, Hu C, Yang Y, Herold T, Qi J, Chen P, Gurbuxani S, Arnovitz S, Strong J, Ferchen K, Ulrich B, Weng H, Wang Y, Huang H, Li S, Neilly MB, Larson RA, Le Beau MM, Bohlander SK, Jin J, Li Z, Bradner JE, Hong S, Chen J. (2016) Eradication of acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles. Cancer Res.76; 4470-4480. PMID: 27280396.

18. Li Z, Chen P, Su R, Hu C, Li Y, Elkahloun AG, Zuo Z, Gurbuxani S, Arnovitz S, Weng H, Wang Y, Li S, Huang H#, Neilly MB, Wang GG, Jiang X, Liu PP, Jin J, Chen J. (2016) PBX3 and MEIS1 cooperate in hematopoietic cells to drive acute myeloid leukemias characterized by a core transcriptome of the MLL-rearranged disease. Cancer Res. 76, 619-629. PMID: 26747896.

19. Huang H, Jiang X#, Wang J, Li Y, Song CX, Chen P, Li S, Gurbuxani S, Arnovitz S, Wang Y, Weng H, Neilly MB, He C, Li Z, Chen J. (2016) Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia. Cancer Lett.372, 157-165. PMID: 26791235.

Year: 2015

1. Ruggeri A, Labopin M, Sanz G, Piemontese S, Arcese W, Bacigalupo A, Blaise D, Bosi A, Huang H#, Karakasis D, Koc Y, Michallet M, Picardi A, Sanz J, Santarone S, Sengelov H, Sierra J, Vincent L, Volt F, Nagler A, Gluckman E, Ciceri F, Rocha V, Mohty M. Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia.Leukemia. 2015.29(9):1891-900.

2. Wang X, Wang Y, Wu X, Wang J, Wang Y, Qiu Z, Chang T, Huang H#, Lin RJ, Yee JK. Nat Biotechnol. Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. Nat Biotechnol. 2015 Feb;33(2):175-8.

3. Piemontese S, Ciceri F, Labopin M, Bacigalupo A, Huang H#, Santarone S, Gorin NC, Koc Y, Wu D, Beelen D, Tischer J, Ehninger G, Arcese W, Nagler A, Mohty M*. A survey on unmanipulated haploidentical hematopoietic stem cell transplantation in adults with acute leukemia. Leukemia. 2015.29(5):1069-75.

4. Hu K, Gu Y, Lou L, Liu L, Hu Y, Wang B, Luo Y, Shi J, Yu X, Huang H*. Galectin-3 mediates bone marrow microenvironment-induced drug resistance in acute leukemia cells via Wnt/β-catenin signaling pathway.J Hematol Oncol. 2015 Jan 27;8(1):1.

5. Gorin NC, Labopin M, Piemontese S, Arcese W, Santarone S, Huang H#, Meloni G, Ferrara F, Beelen D, Sanz M, Bacigalupo A, Ciceri F, Mailhol A, Nagler A, Mohty M. T-cell-replete haploidentical transplantation versus autologous stem cell transplantation in adult acute leukemia: a matched pair analysis. Haematologica. 2015 Apr;100(4):558-64.

6. Zi FM, He JS, Li Y, Wu C, Yang L, Yang Y, Wang LJ, He DH, Zhao Y, Wu WJ, Zheng GF, Han XY, Huang H, Yi Q, Cai Z*. Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in vitro and in xenograft models. Cancer Lett. 2015. 356(2 Pt B):443-53.

7. Chen B, Chen X, Wu X, Wang X, Wang Y, Lin TY, Kurata J, Wu J, Vonderfecht S, Sun G, Huang H#, Yee JK, Hu J, Lin RJ. Disruption of microRNA-21 by TALEN leads to diminished cell transformation and increased expression of cell-environment interaction genes. Cancer Lett.2015. 356(2 Pt B):506-16.

8. Gu Y, Zhou H, Gan Y, Zhang J, Chen J, Gan X, Li H, Zheng W, Meng Z, Ma X, Wang X, Xu X, Xu G, Lu X, Liang Y, Zhang X, Lu X, Huang W*, Xu R*. Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue. Oncotarget. 2015;6:15111-21.

9. Zhou H, Xu R*. Leukemia stem cells: the root of chronic myeloid leukemia. Protein Cell. 2015;6:403-12.

10. Kim, T., Joo, C., Seong, J., Vafabakhsh, R., Botvinick, E.L., Berns, M.W., Palmer, A. E., Wang, N., Ha, T., Sun, J. *, and Wang, Y. * (2015) Distinct mechanisms regulating mechanical force-induced calcium signals at the plasma membrane and endoplasmic reticulum in human mesenchymal stem cells. eLife. (* Co-corresponding authors)

11. Sun, J#. and Sadelain, M. (2015) The quest for spatio-temporal control of CAR T cells. Cell Res.

12. Qi S, Fang Z, Wang D, Menendez P, Yao K*, Ji J*. Concise Review: Induced Pluripotency by defined factors: Prey of Oxidative Stress (2015). Stem Cells 33(5):1371-6.(* Correspondence author).

13. Liu Y*, Chen C*, Qian P*, Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q, Liu S, Zhang H, Zhao F, Wicha MS, Zhu T, Zhao Y. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nat Commun. 2015 Jan 23;6:5988. (*, Co-corresponding authors).

14. Saadatpour A, Lai S, Guo G#, Yuan GC#. Single-Cell Analysis in Cancer Genomics. Trends Genet. 2015 Oct;31(10):576-86. doi: 10.1016/j.tig.2015.07.003. #Co-corresponding authors.

15. Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X#, Wei M, Jin J, Liu PP, Chen J. (2015) Overexpression and knockout of miR-126 both promote leukemogenesis. Blood.126, 2005-2015. PMID: 26361793.

Before 2015 year

1. Luo Y, Xiao H, Lai X, Shi J, Tan Y, He J, Xie W, Zheng W, Zhu Y, Ye X, Yu X, Cai Z#, Lin M, Huang H*. T-cell-replete haploidentical HSCT with low-dose anti-T-lymphocyte globulin compared with matched sibling HSCT and unrelated HSCT. Blood. 2014. 124(17):2735-43.

2. Chen WL, Wang JH, Zhao AH, Xu X, Wang YH, Chen TL, Li JM, Mi JQ, Zhu YM, Liu YF, Wang YY, Jin J, Huang H#, Wu DP, Li Y, Yan XJ, Yan JS, Li JY, Wang S, Huang XJ, Wang BS, Chen Z, Chen SJ, Jia W. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. Blood. 2014 Sep 4;124(10):1645-54.

3. Hu J, Lei Y, Wong WK, Liu S, Lee KC, He X, You W, Zhou R, Guo JT, Chen X, Peng X, Sun H, Huang H#, Zhao H, Feng B. Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Res. 2014 Apr;42(7):4375-90.

4. Wu K, Wang Y, He Y, Hu Y, Fu H, Sheng L, Wang B, Fu S, Huang H*. Dasatinib promotes the potential of proliferation and antitumor responses of human γδT cells in a long-term induction ex vivo environment.Leukemia. 28(1):206-210. 2014.

5. Hu Y, Cui Q, Gu Y, Sheng L, Wu K, Shi J, Tan Y, Fu H, Liu L, Fu S, Yu X, Huang H*. Decitabine facilitates the generation and immunosuppressive function of regulatory gammadeltaT cells derived from human peripheral blood mononuclear cells. Leukemia. 27(7): 1580-1585. 2013.

6. Xiao H, Shi J,Luo Y, Tan Y, He J, Xie W, ZhangL, Wang Y, Liu L, Wu K, Yu X, Cai Z, Lin M, Ye X, Huang H*. First report of multiple CEBPA mutations contributing to donor origin of leukemia relapse after allogeneic hematopoietic stem cell transplantation. Blood. 117(19): 5257-5260. 2011.

7. Luo Y, Lai X, Tan Y, Shi J, Zhao Y, Han X, Zheng G, Zhu X, Sun J, Zheng Y, Wu G, He J, Chen S, Jin A, Xie W, Ye X, Cai Z, Lin M, Huang H*. Reduced-intensity allogeneic transplantation combined with imatinibmesylate for chronic myeloid leukemia in first chronic phase. Leukemia. 23(6):1171-1174. 2009.

8. Wang L, Xiao H, Zhang X, Wang C, Huang H*.The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation. J Hematol Oncol. 2014 Aug 20;7:61.

9. Zhao Y, Huang H, Wei G*. Novel agents and biomarkers for acute lymphoid leukemia. J HematolOncol. 6:40. 2013.

10. Xiao H, Luo Y, Lai X, Fu S, Shi J, Tan Y, He J, Xie W, Zheng W, Wang L, Zhang L, Liu L, Ye X, Yu X, Cai Z, Lin M, Huang H*. Genetic variations in T-cell activation and effector pathways modulate alloimmune responses after allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies.Haematologica.97 (12):1804-1812. 2012.

11. Chang T, Zheng W, Tsark W, Bates S, Huang H#, Lin R, Yee JK*. Phenotypic rescue of Induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient. Stem Cells. 29: 2090-2093. 2011.

12. Wei G, Ni W, Chiao J, Cai Z, Huang H#， Liu D*. Ameta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome. J HematolOncol, 4: 46. 2011.

13. Yu J, Lan J, Wang C, Wu Q, Zhu Y, Lai X, Sun J, Jin C*, Huang H*. PML3 interacts with TRF1 and is essential for ALT-associated PML bodies assembly in U2OS cells. Cancer Lett. 291(2): 177-186. 2010.

14. Cheng Z, Ke Y, Ding X, Wang F, Wang H, Wang W, Ahmed K, Liu Z, Xu Y, Aikhionbare F, Yan H, Liu J, Xue Y, Yu J, Powell M, Liang S, Wu Q, Reddy SE, Hu R, Huang H#, Jin C, Yao X*. Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. Oncogene. 27(7): 931-941. Feb 2008.

15. Fu C, Ahmed K, Ding H, Ding X, Lan J, Yang Z, Miao Y, Zhu Y, Shi Y, Zhu J, Huang H*, Yao X*. Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3. Oncogene. 24(35): 5401-5413. Aug 2005

16. Chen T, Meng Z, Gan Y, Wang X, Gu Y, Xu X, Tang J, Zhou H, Zhang X, Gan X, Van Ness C, Xu F, Xu G, Huang L, Zhang X, Fang Y, Wu J, Zheng S, Jin J, Huang W*, Xu R*.The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells. Leukemia. 2013，27(1):1469-78.

17. Gu Y, Chen T, Meng Z, Gan Y, Xu X, Lou G, Li H, Gan X, Zhou H, Tang J, Xu G, Huang L, Zhang X, Fang Y, Wang K, Zheng S, Huang W*, Xu R*. CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine. Blood. 2012，120(24):4829-39.

18. Meng Z, Wang X, Gan Y, Zhang Y, Zhou H, Ness CV, Wu J, Lou G, Yu H, He C, Xu R*, Huang W*. Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol. 2012, 57(5):1004-12.

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